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Extended hildebrand solubility approach: Solubility of theophylline in polar binary solvents

✍ Scribed by A. Martin; J. Newburger; A. Adjei

Publisher
John Wiley and Sons
Year
1980
Tongue
English
Weight
571 KB
Volume
69
Category
Article
ISSN
0022-3549

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value for 8-chloro-6-phenyl-4H-s-triazolo[4,3-a J\1,4] benzodiazepine (estazolam) was reported to be 2.84 from the UV absorption spectral change (23). Considering the structural difference mentioned, the estimated pKa value for triazolam, 1.52, is reasonable. The bioavailability or the pharmacologi