The aim of this work was to study the expression of ␣, 1, and 4 integrin subunits in meningiomas.
METHODS.
Seventeen atypical or anaplastic meningiomas were retrieved from the files of Ho ˆpital de Bellevue, Saint-Etienne, France. They were compared with 17 benign meningiomas consecutively examined in 1997 and 6 schwannomas. The tumors were classified according to standard histologic criteria. Frozen sections were immunostained for ␣1, ␣2, ␣3, ␣4, ␣5, ␣6, 1, and 4 integrin subunits; collagen; laminin and fibronectin; cytokeratin; vimentin; neural cell adhesion molecule (NCAM); and MIB-1.
RESULTS.
The study included 7 fibrous meningiomas, 6 transitional meningiomas, 19 syncytial meningiomas, and 2 secretory meningiomas. The expression of ␣1, ␣3, ␣5, ␣6, and 1 was constant. The expression of ␣1 was higher in fibrous meningiomas than in syncytial meningiomas. Only in transitional, syncytial, and secretory meningiomas was the expression of ␣2 detected. The expression of ␣2 and 4 was associated with the expression of cytokeratin in the glandular structures of secretory meningiomas, whereas it was associated with NCAM expression in the whorls of meningothelial meningiomas. The expression of integrin receptors by tumor cells was strongly correlated with that of their respective ligands in the extracellular matrix. In invasive meningiomas, the expression of ␣3 and ␣6 by tumor cells was significantly lower. The higher the MIB-1 proliferation index, the lower the expression of ␣3. The 6 schwannomas expressed only ␣2, ␣3, ␣6, 1, and 4 integrins.
CONCLUSIONS.
Each histologic subtype of meningioma has a specific spectrum of integrin expression. The study of ␣3 and ␣6 may have prognostic value in the assessment of meningiomas. The study of the integrin profile is valuable for the differential diagnosis of fibrous meningiomas and schwannomas.