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Expression of αB-crystallin in human brain tumors

✍ Scribed by Akira Aoyama; Rudolf H. Steiger; Erika Fröhli; Reinhold Schäper; Andreas Deimling; Otmar D. Wiestler; Roman Klemenz

Publisher
John Wiley and Sons
Year
1993
Tongue
French
Weight
717 KB
Volume
55
Category
Article
ISSN
0020-7136

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✦ Synopsis

We have previously shown that aB-crystallin is a heat-shock protein which specifically accumulates in response to the expression of c-Ha-ras and v-mos oncogenes in mouse NIH 3T3 fibroblasts. Elevated levels of aB-crystallin mRNA or protein were shown to be associated with pathological conditions of the brain. Therefore, we have examined the expression of a6crystallin in normal human brains and brain tumors by Western blot analysis. aB-crystallin is moderately expressed in adult but not fetal brain. Elevated levels of aB-crystallin expression are observed in glial tumors such as astrocytoma, glioblastoma rnultiforme, and oligodendroglioma. aB-crystallin in these tumors is predominately unphosphorylated. High amounts of accumulated aB-crystallin in astrocytic tumors are preferentially found in the more aggressive stages. Glioblastoma multiforme is exceptional in that high aB-crystallin expression is observed in only one half of the analyzed samples whereas no aB-crystallin could be detected in the other. These results indicate that aB-crystallin may be a useful biochemical marker for studying the pathogenesis of various human brain tumors.

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