Expression of xenobiotic-metabolizing cytochrome P450 (CYP) enzymes in human CD34+ bone marrow stem cells
β Scribed by Ulrike Bernauer; Henk Garritsen; Ursula Gundert-Remy
- Book ID
- 119378496
- Publisher
- Elsevier Science
- Year
- 2006
- Tongue
- English
- Weight
- 77 KB
- Volume
- 164
- Category
- Article
- ISSN
- 0378-4274
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Bone marrow stroma is the physical basis of the haematopoietic microenvironment and regulates several key features of stem cell proliferation and differentiation. It plays a crucial role in maintaining haematopoietic homeostasis. Earlier studies have shown that this is achieved through interactions
## Abstract A human lymphoblastoid cell line stably expressing a human cytochrome P4501A2 cDNA was developed. This recombinant cell line displayed P4501A2 protein and estradiol2βhydroxylase activity, neither of which was detected in the parental cell line. The recombinant cell line was also approxi