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Expression of Wilms tumor 1 gene in a variety of pediatric tumors

✍ Scribed by Takaharu Oue; Shuichiro Uehara; Hiroaki Yamanaka; Yuichi Takama; Yusuke Oji; Masahiro Fukuzawa

Book ID
116689321
Publisher
Elsevier Science
Year
2011
Tongue
English
Weight
930 KB
Volume
46
Category
Article
ISSN
0022-3468

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## Abstract The Wilms' tumor 1 gene, __WT1__, encodes a zinc‐finger protein that is implicated in the development of Wilms' tumor. Mutant or aberrantly expressed WT1 isoforms have also been described in desmoplastic small round cell tumor, acute leukemias, mesothelioma, breast tumors and melanoma.

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## Abstract Desmoid tumors (aggressive fibromatosis) are locally invasive soft tissue tumors in which β‐catenin/TCF3 mediated Wnt signaling is activated. More than 80% of desmoid tumors contain activating mutations in β‐catenin. It has been shown that the Wnt signaling pathway interacts with Wilms'