We have previously observed that acellular extracts from necrotic areas (NE) of the non-metastatic murine mammary adenocarcinoma M3, enhance in vitro cell detachment and spontaneous lung metastases. In the present study, using different proteinase inhibitors along with NE, only the calcium chelator
✦ LIBER ✦
Expression of type IV collagenases in invasive tumors
✍ Scribed by K. Tryggvason; P. Huhtala; P. Reponen; C. Munaut; C. Pyke; K. Danø; H. Autio-Harmainen
- Book ID
- 115894517
- Publisher
- Elsevier Science
- Year
- 1992
- Tongue
- English
- Weight
- 127 KB
- Volume
- 55
- Category
- Article
- ISSN
- 0014-4835
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Collagenases are a family of metalloproteinases which may play a role in facilitating tumor cell invasion of the extracellular matrix. Tumor cells traverse two types of extracellular matrix: basement membranes and interstitial stroma, at multiple stages of the metastatic process. The matrix is a den