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Expression of two myogenic regulatory factors myogenin and MyoDl during mouse embryogenesis

✍ Scribed by Sassoon, David; Lyons, Gary; Wright, Woodring E.; Lin, Victor; Lassar, Andrew; Weintraub, Harold; Buckingham, Margaret

Book ID
109761212
Publisher
Nature Publishing Group
Year
1989
Tongue
English
Weight
946 KB
Volume
341
Category
Article
ISSN
0028-0836

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✦ Synopsis

MyoD1 and myogenin are muscle-specific proteins which can convert non-myogenic cells in culture to differentiated muscle fibres, implicating them in myogenic determination. The pattern of expression of MyoD1 and myogenin during the early stages of muscle formation in the mouse embryo in vivo and in limb-bud explants cultured in vitro, indicates that they may have different functions in different types of muscle during development.

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## Abstract It is known that the MyoD family members (MyoD, Myf5, myogenin, and MRF4) play a pivotal role in the complex mechanism of skeletal muscle cell differentiation. However, fragmentary information on transcription factor‐specific regulation is available and data on their post‐transcriptiona