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Expression of transglutaminase 1 in human hair follicles, sebaceous glands and sweat glands

✍ Scribed by Yoneda; Akiyama; Morita; Shimizu; Imamura; Kim

Publisher
John Wiley and Sons
Year
1998
Tongue
English
Weight
822 KB
Volume
138
Category
Article
ISSN
0007-0963

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✦ Synopsis

To explore the function of the enzyme transglutaminase 1 (TGase 1), its distribution was analysed by immunofluorescence microscopy, postembedding immunoelectron microscopy and in situ hybridization. TGase 1 was expressed in the outer root sheath (ORS) cells in the distal portion of the isthmus and infundibulum of human hair follicles. In the level of the proximal and middle portion of the isthmus, TGase 1 was observed in the keratinized area of the inner root sheath (IRS) and ORS cells. In the bulbar and suprabulbar portions, TGase 1 was present in the ORS and IRS cells. The cortex and medulla cells in these regions also contained TGase 1. A high level of fluorescence was observed at the cuticle of the cortex. Sebaceous and sweat gland cells contained abundant TGase 1. Possible functions of TGase 1 in these epidermal appendages are discussed.

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