✦ LIBER ✦

Expression of transformation in cell hybrids. II. Nonsuppression of the transformed phenotype in hybrids between a chemically transformed and nontransformed derivatives of Balb/3T3

✍ Scribed by Krishna K. Jha; Janice Cacciapuoti; Harvey L. Ozer

Publisher: John Wiley and Sons
Year: 1978
Tongue: English
Weight: 565 KB
Volume: 97
Category: Article
ISSN: 0021-9541
DOI: 10.1002/jcp.1040970203

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Hybrid clones derived from a nitrosocarbaryl‐transformed Balb/3T3 cell line, Clone H, and a nontransformed cell line TH02 resemble the transformed parent in the clone morphology, higher saturation density, colony formation in medium with reduced serum concentration, growth in agarose and ability to form clones on Balb/3T3 monolayer. Results are discussed in the framework of genetic models which permit or require dominant mutations for the expression of transformed phenotype.

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