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Expression of Toll-Like Receptor 2 and 4 in Inflamed Pulp in Severe Combined Immunodeficiency Mice

✍ Scribed by Noriko Mutoh; Hirotaka Watabe; Keiko Chieda; Nobuyuki Tani-Ishii

Book ID: 116677423
Publisher: Elsevier Science
Year: 2009
Tongue: English
Weight: 560 KB
Volume: 35
Category: Article
ISSN: 0099-2399
DOI: 10.1016/j.joen.2009.04.005

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## Abstract C57BL/10ScCr (Cr) mice carry a deletion of the Toll‐like receptor 4 (__tlr4__) gene (i.e. they are __tlr4__^0/0^) and are thus refractory to LPS effects. Insertion of wild‐type __tlr4__ transgene into the __tlr4__^0/0^ Cr germ line endowed LPS susceptibility in the two transgenic lines