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Expression of tissue factor correlates with grade of malignancy in human glioma

✍ Scribed by Kazuya Hamada; Jun-ichi Kuratsu; Yoshiki Saitoh; Hideo Takeshima; Toru Nishi; Yukitaka Ushio

Publisher
John Wiley and Sons
Year
1996
Tongue
English
Weight
735 KB
Volume
77
Category
Article
ISSN
0008-543X

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✦ Synopsis

BACKGROUND. Tissue factor (TF), a cell surface receptor of factor VIIIVIIa, was initially recognized as an initiator of the extrinsic coagulation pathway. TF has recently been found to be expressed highly in certain types of malignant tumors. In addition, TF belongs to the interferon receptor family and is one of the immediate early genes, suggesting that TF may participate in the regulation of cell growth. However, the correlation between the expression of TF and cell growth is still unclear.

METHODS.

Expression of TF in 6 glioma cell lines and 44 glioma surgical specimens was studied by Northern blot analysis, Western blot analysis, immunohistochemistry, and in situ hybridization.

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