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Expression of the tumor-rejection antigen SART1 in brain tumors

✍ Scribed by Toshihiro Imaizumi; Terukazu Kuramoto; Kazuko Matsunaga; Shigeki Shichijo; Shigeru Yutani; Minoru Shigemori; Koutaro Oizumi; Kyogo Itoh

Publisher: John Wiley and Sons
Year: 1999
Tongue: French
Weight: 156 KB
Volume: 83
Category: Article
ISSN: 0020-7136
DOI: 10.1002/(sici)1097-0215(19991210)83:6<760::aid-ijc11>3.0.co;2-r

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✦ Synopsis

We have reported a tumor-rejection antigen, SART1 259 , possessing tumor epitopes capable of inducing cytotoxic T lymphocytes (CTLs) in epithelial-cancer patients. This study investigated the expression of SART1 259 antigen in brain tumors, to explore for a potential molecule for use in specific immunotherapy of patients with brain tumors. The SART1 259 antigen was detected in the cytosol fraction of 13 of 18 (72%) glioma cell lines and in 12 of 34 (35%) brain-tumor tissues, with a higher rate of expression among malignant gliomas (5/10, 50%) and schwannomas (3/4). HLA-A24-restricted and SART1-specific CTLs recognized the HLA-A24 ؉ and SART1 259 ؉ glioma cells, and the levels of recognition correlated both with HLA-A24-antigen expression level and with the concentration of the SART1 peptide antigen. Therefore, the SART1 259 antigen could be a target molecule for specific immunotherapy of patients with brain tumors expressing HLA-class-I antigens.

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