Expression of the SART-1 tumor rejection antigen in breast cancer

✍ Scribed by Mayumi Kawamoto; Shigeki Shichijo; Yasuhisa Imai; Toshihiko Imaizumi; Toshihiro Koga; Hiroshi Yanaga; Kyogo Itoh

• Publisher: John Wiley and Sons
• Year: 1999
• Tongue: French
• Weight: 127 KB
• Volume: 80
• Category: Article
• ISSN: 0020-7136
• DOI: 10.1002/(sici)1097-0215(19990105)80:1<64::aid-ijc13>3.0.co;2-7

✦ Synopsis

We investigated in breast cancers the expression of the SART-1 gene encoding tumor rejection antigens. SART-1 mRNA was expressed in all of the samples tested. The SART-1 800 antigen was detectable in 20 of 50 (40%) breast cancer tissues and all breast cancer cell lines tested, but not in normal breast tissues. The SART-1 800 ؉ breast cancer cells transfected with HLA-A2601 or HLA-A2402 cDNA were recognized by the HLA-A26-restricted and SART-1-specific cytotoxic T lymphocytes (CTLs) or the HLA-A24-restricted and SART-1-specific CTLs, respectively. Among the 20 SART-1 800 ؉ tumors, 9 or 8 tumors expressed estrogen receptor or progesterone receptor, respectively. Therefore, the patients with HLA-A26 or -A24 haplotype might be appropriate candidates for specific immunotherapy with the SART-1 peptides independently or in combination with hormone therapy. Int.