Expression of the translation initiation factors eIF-4E and eIF-2α is frequently increased in neoplastic cells of Hodgkin lymphoma
✍ Scribed by Igor B. Rosenwald; Larisa Koifman; Lou Savas; Jane-Jane Chen; Bruce A. Woda; Marshall E. Kadin
- Book ID
- 116534468
- Publisher
- Elsevier Science
- Year
- 2008
- Tongue
- English
- Weight
- 965 KB
- Volume
- 39
- Category
- Article
- ISSN
- 1532-8392
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## Abstract ## BACKGROUND Stimulation of resting cells by growth factors leads to an increase in the rate of protein synthesis, which is necessary for cell growth and division. Translation initiation factor eIF‐2α is one of the key translation factors mediating the effects of growth factors on pro
## BACKGROUND. When resting cells are stimulated by growth factors, an increase in protein synthesis follows that depends in part on two key eukaryotic translation initiation factors, 4E and 2␣ (eIF-4E and eIF-2␣, respectively). In the normal cell, expression and activity of both factors are incre