Peripheral myelin protein 22 (PMP22) is a small, hydrophobic glycoprotein, which is most prominently expressed by Schwann cells as a component of compact myelin of the peripheral nervous system (PNS). Recent progress in molecular genetics revealed that mutations affecting the PMP22 gene including du
Expression of the peripheral myelin protein 22 (PMP-22) during myelin development in two weeks old mice
✍ Scribed by H. Grehl; D. Bächner; T. Liehr; H. Hameister; B. Rautenstrauβ
- Book ID
- 119108977
- Publisher
- Elsevier Science
- Year
- 1994
- Tongue
- English
- Weight
- 146 KB
- Volume
- 54
- Category
- Article
- ISSN
- 0165-5728
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Peripheral myelin protein 22 (PMP22) was initially described as a minor component of peripheral myelin. Mutations affecting the PMP22 gene cause demyelinating neuropathies, supporting a role for the protein in PNS myelination. Furthermore, PMP22 carries the L2/HNK-1 carbohydrate epitope suggesting a
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