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Expression of the Human Cholesterol 7α-Hydroxylase Gene in Transgenic Mice

✍ Scribed by Sheryl A. Goodart; Cathy Huynh; Wei Chen; Allen D. Cooper; Beatriz Levy-Wilson

Book ID
115584892
Publisher
Elsevier Science
Year
1999
Tongue
English
Weight
169 KB
Volume
266
Category
Article
ISSN
0006-291X

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Cholesterol 7a-hydroxylase (CYP7A1) is the rate-limiting enzyme in the bile acid biosynthetic pathway that converts cholesterol into bile acids in the liver. Recent studies have shown that bile acids may play an important role in maintaining lipid, glucose, and energy homeostasis. However, the role