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Expression of the HER-2/neu proto-oncogene in serous ovarian neoplasms

✍ Scribed by Jeffrey D. Seidman; Dennis M. Frisman; Henry J. Norris

Publisher
John Wiley and Sons
Year
1992
Tongue
English
Weight
506 KB
Volume
70
Category
Article
ISSN
0008-543X

No coin nor oath required. For personal study only.

✦ Synopsis

Background. It is unclear whether HER-O/neu proto-oncogene expression in ovarian epithelial neoplasms is related to prognosis.

Methods. The authors performed immunohistochemical stains on 20 serous tumors of low malignant potential (STLMP) in Stages I and I1 and 19 serious carcinomas in the same stages. They used three different commercial antibodies to make comparisons.

Two of four Stage I STLMP in patients who experienced disease progression showed positive staining for the gene product, whereas none of seven Stage I nonprogressive STLMP showed positive staining. Five of the six Stage I11 nonprogressive STLMP showed positive staining, whereas none of three Stage I11 STLMP that progressed showed positive staining. Three carcinomas (one Stage I and two Stage 111) also showed positive staining.

Expression of HER-2/neu may be associated with high stage in serous ovarian neoplasms, but it is not likely to identify the small fraction of patients with STLMP who will experience disease progression. Cancer 1992; 70:2857-60.

Results.

Conclusions.

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