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Expression of the hepatitis B virus surface antigen in mammalian cells using an Epstein-Barr-virus-derived vector

✍ Scribed by S. A. C. Jorge, C. Hera, A. M. M. Spina…

Book ID
120768395
Publisher
Springer
Year
1996
Tongue
English
Weight
221 KB
Volume
46
Category
Article
ISSN
1432-0614

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We have constructed a recombinant SV40-based vector carrying the S gene coding for the hepatitis B virus surface antigen (HBsAg). This vector replicates as an episome in monkey COS7 cells, producing high levels of hepatitis B virus surface antigen (HBsAg), which is liberated in the cell medium, prob