Expression of the c-erbB-3 protein in human breast cancer cell lines
โ Scribed by T. Rajkumar; W.J. Gullick
- Book ID
- 113404292
- Publisher
- Elsevier Science
- Year
- 1993
- Tongue
- English
- Weight
- 161 KB
- Volume
- 2
- Category
- Article
- ISSN
- 0960-9776
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The c-erbB-2 proto-oncogene is amplified in a high percentage of primary human breast tumors, suggesting that the overexpression of this gene may be involved in the development of human breast cancer. We have investigated five human breast tumor cell lines and have detected amplified c-erbB-2 gene c
Ebp1, an ErbB-3 binding protein, translocates from the cytoplasm to the nucleus of human breast cancer cells after treatment with the ErbB-3 ligand, heregulin. The purpose of these studies was to examine the effects of ectopic expression of ebp1 on the biological properties of human ErbB-3-expressin