Expression of the angiogenic factor thymidine phosphorylase in human astrocytic tumors
β Scribed by S. Takano; K. Tsuboi; A. Matsumura; Y. Tomono; Y. Mitsui; T. Nose
- Publisher
- Springer-Verlag
- Year
- 2000
- Tongue
- English
- Weight
- 266 KB
- Volume
- 126
- Category
- Article
- ISSN
- 1432-1335
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We have investigated the expression of platelet-derived endothelial-cell growth factorkhymidine phosphorylase (PD-ECGF/dThdPase) in human breast-cancer tissues by the immunocytochemical method using anti-PD-ECGF/ dThdPase monoclonal antibody. Out of I00 invasive-ductal-carcinoma tissue samples, 39 (
## Abstract Uridine phosphorylase (UPase) and an angiogenic enzyme, thymidine phosphorylase (dThdPase) are involved in degradation of the pyrimidine nucleosides through phosphorolysis. The expression levels of UPase and dThdPase are higher in human solid tumors including breast carcinomas than in n