Expression of spermidine/spermine N1-acetyltransferase in HeLa cells is regulated by amino acid sufficiency
✍ Scribed by Corinne Aubel; Hervé Chabanon; Valérie Carraro; Heather M. Wallace; Patrick Brachet
- Book ID
- 117756058
- Publisher
- Elsevier Science
- Year
- 2003
- Tongue
- English
- Weight
- 208 KB
- Volume
- 35
- Category
- Article
- ISSN
- 1357-2725
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📜 SIMILAR VOLUMES
Spermidine/spermine N 1 -acetyltransferase (cSAT), a key enzyme in polyamine degradation, is induced by various hepatotoxins and liver tumor promoters. In this paper we demonstrate that physiological factors, such as cytokines, control cSAT expression in HepG2 human hepatocarcinoma cells. Hepatocyte
Activity and messenger RNA levels of spermidine/spermine N'-acetyltransferase, the rate-limiting enzyme of the polyamine interconversion pathway, were investigated in host liver and in Yoshida AH-130 ascites hepatoma cells as a function of tumor growth phases. Enzyme activity reached maximal values