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Expression of sonic hedgehog signal transducers, patched and smoothened, in human basal cell carcinoma

โœ Scribed by Michiko Tojo; Tetsuji Mori; Hidenori Kiyosawa; Yutaka Honma; Yoshihiro Tanno; Ken-ya Kanazawa; Sachihiko Yokoya; Fumio Kaneko; Akio Wanaka


Book ID
114430905
Publisher
John Wiley and Sons
Year
1999
Tongue
English
Weight
420 KB
Volume
49
Category
Article
ISSN
1320-5463

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Mutations in the human homologue of Drosophila patched (PTCH) have been identified in patients with nevoid basal cell carcinoma syndrome (NBCCS; also called Gorlin syndrome) as well as sporadic basal cell carcinomas and medulloblastomas. However, using PCR-SSCP analysis, mutations in PTCH have been