Light-induced aggregation of type I solu
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Shouvik Roy; Bruce D. Mason; Christian S. SchΓΆneich; John F. Carpenter; Thomas C
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Article
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2009
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John Wiley and Sons
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English
β 342 KB
We evaluated the effect of UV-B light at 302 nm on a model therapeutic protein, 2.6 D type I soluble tumor necrosis factor receptor (sTNF-RI). This protein contains a single Trp at position 97 and seven native disulfide bonds along its interior from the N to the C-terminus. At a protein concentratio