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Expression of pro-inflammatory TACE-TNF-α-amphiregulin axis in Sjögren’s syndrome salivary glands

✍ Scribed by Margherita Sisto; Sabrina Lisi; Dario Domenico Lofrumento; Giuseppe Ingravallo; Vincenzo Mitolo; Massimo D’Amore

Publisher: Springer
Year: 2010
Tongue: English
Weight: 625 KB
Volume: 134
Category: Article
ISSN: 1432-119X
DOI: 10.1007/s00418-010-0735-5

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## Abstract ## Objective To clarify the molecular mechanisms of Sjögren's syndrome (SS), we analyzed the functional role of the STAT‐1 gene, one of the interferon‐γ (IFNγ)–inducible genes, in labial salivary glands (LSGs) from SS patients. ## Methods The expression of STAT‐1 messenger RNA (mRNA)