## Abstract Increased capillary shear stress induces angiogenesis in skeletal muscle, but the signaling mechanisms underlying this response are not known. We hypothesize that shear stressβdependent activation of vascular endothelial growth factor receptor 2 (VEGFR2) causes p38 and ERK1/2 phosphoryl
Expression of Platelet-Activating Factor Receptor Transcript-2 Is Induced by Shear Stress in HUVEC
β Scribed by Kazuhiro Okahara; Bing Sun; Tomio Kawasaki; Morito Monden; Jun-ichi Kambayashi
- Book ID
- 114100954
- Publisher
- Elsevier Science
- Year
- 1998
- Tongue
- English
- Weight
- 205 KB
- Volume
- 55
- Category
- Article
- ISSN
- 0090-6980
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Excessive nitric oxide (NO) generated by hepatic cells in response to lipopolysaccharide (LPS) and inflammatory substances (e.g., platelet-activating factor [PAF]) is a key contributor to the pathophysiological outcomes observed in the liver during sepsis. In rats subjected to liver-focused endotoxe