𝔖 Bobbio Scriptorium
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Expression of plasmolipin in the developing rat brain

✍ Scribed by Dr. V. S. Sapirstein; C. E. Nolan; I. I. Stadler; I. Fischer

Publisher
John Wiley and Sons
Year
1992
Tongue
English
Weight
676 KB
Volume
31
Category
Article
ISSN
0360-4012

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✦ Synopsis

Plasmolipin is an hydrophobic plasma membrane proteolipid present in both kidney and brain. The protein consists of two subunits of 17-18.5 kD, which together form K + selective voltage-dependent channels. In this report, we define the embryonic and postnatal expression of plasmolipin in the developing rat brain. Plasmolipin was found to be essentially restricted to the postnatal period increasing eight-fold between the first to fourth week after birth. A fetal plasmolipin immunoreactive protein (FPIP) was identified in embryonic brain and also during the early postnatal development of the cerebellum. The expression of FPIP was biphasic with an initial transient increase between EWE20 followed by a decrease in its levels. FPIP was not detected in the developed rat CNS. FPIP was found in a variety of dividing and immature cells including cultured astrocytes and embryonic neurons, neuroblastoma cells, and rat thymus. In contrast, plasmolipin was restricted to oligodendrocytes of the neural cells tested and to renal tubular epithelial cells.

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