## Abstract In conditions in which the retinal pigment epithelium (RPE) is dystrophic, carries a genetic mutation, or is removed physically, Mรผller cells undergo degenerative changes that contribute to the retinal pathology. We previously demonstrated that pigment epitheliumโderived factor (PEDF),
Expression of pigment-epithelium-derived factor during kidney development and aging
โ Scribed by Ana Luisa Pina; Marion Kubitza; Alexander Brawanski; Joyce Tombran-Tink; Sabine Kloth
- Publisher
- Springer-Verlag
- Year
- 2007
- Tongue
- English
- Weight
- 525 KB
- Volume
- 329
- Category
- Article
- ISSN
- 0302-766X
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Pigment epithelium-derived factor (PEDF) is one of the most powerful endogenous antiangiogenic reagents discovered to date. Its antiangiogenic potential in neoplastic disease remains unclear. In this study, we investigated antiangiogenic property of PEDF in hepatocellular carcinoma (HCC), a typical
Pigment epithelium-derived factor (PEDF) is a member of the serine protease inhibitor (serpin) superfamily that has been shown previously to promote the survival and/or differentiation of rat cerebellar granule neurons and human retinoblastoma cells in vitro. However, in contrast to most serpins, PE