## Abstract In conditions in which the retinal pigment epithelium (RPE) is dystrophic, carries a genetic mutation, or is removed physically, Müller cells undergo degenerative changes that contribute to the retinal pathology. We previously demonstrated that pigment epithelium‐derived factor (PEDF),
Differential expression of angioregulatory factors in normal and CNV-derived human retinal pigment epithelium
✍ Scribed by Gottfried Martin; Günther Schlunck; LutzL. Hansen; HansjürgenT. Agostini
- Publisher
- Springer-Verlag
- Year
- 2004
- Tongue
- English
- Weight
- 299 KB
- Volume
- 242
- Category
- Article
- ISSN
- 0065-6100
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## Abstract The role of insulin‐like growth factors (IGF) in regulating cell differentiation and proliferation is in part modulated by the IGF binding protein (IGFBP) family of genes. Previous studies of the human retinal pigment epithelium (RPE) have detected expression of IGFBP‐2, ‐3, and ‐6. How
## Abstract Pigment epithelium‐derived factor (PEDF), a glycoprotein with pleiotropic functions, is naturally occuring in the eye and considered as crucial to prevent pathological angiogenesis. Since retinal glial (Müller) cells produce PEDF, the authors have studied its impact on glial–endothelial