Expression of p21 WAF1/CIP1 in Bladder Cancer: Relation to Schistosomiasis
โ Scribed by Sanaa Eissa; Menha Swelam; Y. Shaker; M. Abdel Fattah; A. Khalifa
- Book ID
- 111743255
- Publisher
- John Wiley and Sons
- Year
- 1999
- Tongue
- English
- Weight
- 240 KB
- Volume
- 48
- Category
- Article
- ISSN
- 1521-6543
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In addition to the tumor suppressor gene p53, Cyclin Dependent Kinases (CDK) are well known to influence the cell cycle in normal human tissues and various neoplasias as well. The purpose of our present study was to evaluate the expression of the CDK-inhibitor p21/waf1/cip1 in colorectal cancer with
BACKGROUND. p21(waf1/cip1) protein is a cyclin-dependent kinase inhibitor able to arrest the cell cycle at the G1 phase by inhibiting DNA replication. The expression of p21(waf1/cip1) and its prognostic value in prostate cancer are largely unexplored. METHODS. We used immunohistochemistry to analyze