Expression of P-glycoprotein influences resistance against anthracyclines in clinical gastric carcinomas

✍ Scribed by Hiroyuki Orita; Yoshihiko Maehara; Hideaki Anai; Hideo Baba; Hiroki Kusumoto; Daisuke Korenaga; Keizo Sugimachi

• Publisher: John Wiley and Sons
• Year: 1994
• Tongue: English
• Weight: 567 KB
• Volume: 10
• Category: Article
• ISSN: 8756-0437
• DOI: 10.1002/ssu.2980100215

✦ Synopsis

In 58 human gastric cancers, the expression of P-glycoprotein (P-gp) was evaluated immunohistochemically and chemosensitivity was determined using the in vitro succinate dehydrogenase inhibition (SDI) test. Tumors which contained over 75% stained cells were scored as positive, and 14 of 58 cases (24%) were positive. There was no significant correlation between P-gp expression and clinicopathologic features. The succinate dehydrogenase (SD) activity for each drug of P-gp positive and negative tumors was as follows: 81.8 k 15.2% vs. 66.3 k 16.1% for Adriamycin (ADM), 75.5 f 14.2% vs. 59.1 k 17.6% for aclacinomycin A (ACR), 71.7 f 15.0% vs. 61.1 _+ 14.0% for mitomycin C (MMC), and 57.5 ? 18.4% vs. 47.0 k 16.7% for cisplatin (CDDP). The increase in SD activity was evident in P-gp positive tumors compared with negative ones in cases of ADM (P = 0.0044), ACR ( P = O.OlOS), and MMC (P = 0.0353). We suggested that P-gp expression is closely related to chemosensitivities of human gastric cancers to anthracyclines.