Glycation of rat sciatic nerve tubulin i
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N. A. Cullum; J. Mahon; K. Stringer; W. G. McLean
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Article
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1991
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Springer
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English
⚖ 325 KB
Diabetic neuropathy is associated with some early defects of axonal transport in experimental animals. Axonal transport is dependent on intact microtubules, and unsubstituted lysine residues of tubulin are essential for microtubule polymerization. As lysine residues are the major target for the non-