Diabetic neuropathy is associated with some early defects of axonal transport in experimental animals. Axonal transport is dependent on intact microtubules, and unsubstituted lysine residues of tubulin are essential for microtubule polymerization. As lysine residues are the major target for the non-
✦ LIBER ✦
Effect of experimental diabetes and insulin on phosphatidylinositol synthesis in rat sciatic nerve
✍ Scribed by John S. Hothersall; Patricia McLean
- Book ID
- 118314183
- Publisher
- Elsevier Science
- Year
- 1979
- Tongue
- English
- Weight
- 553 KB
- Volume
- 88
- Category
- Article
- ISSN
- 0006-291X
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## Abstract In a long‐term study using cyclosporin‐A (Cy‐A) as immunosuppressant in a dose of 10 mg/kg/day, pancreas‐duodenum was transplanted from Brown Norway donors to alloxan‐diabetic Lewis rats (n = 190). The pancreas transplants (PT) were performed after 1, 3, 6, 9, 12, and 15 months of diabe