Expression of melanoma-associated antigens in oral squamous cell carcinoma
✍ Scribed by Jutta Ries; Eleftherios Vairaktaris; Nur Mollaoglu; Joerg Wiltfang; Friedrich W. Neukam; Emeka Nkenke
- Book ID
- 111255093
- Publisher
- John Wiley and Sons
- Year
- 2007
- Tongue
- English
- Weight
- 175 KB
- Volume
- 37
- Category
- Article
- ISSN
- 0904-2512
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## Abstract ## Background Apoptosis is a genetically programmed form of cell death, of which caspases are the central components. ## Methods By tissue microarray of 229 cases of oral squamous cell carcinoma (OSCC), we analyzed the immunoexpression of caspases 3, 6, 7, 8, 9, and 10. ## Results
The ABH isoantigen was investigated in 80 patients with squamous cell carcinoma of the oral cavity and in their 46 affected lymph nodes. Isoantigen deletion shows a characteristic pattern of benign to malignant transformation of oral cancer. Total loss of isoantigen was found in anaplastic tumours,
## Abstract ## Objectives/Hypothesis: Previous studies have demonstrated a relationship between elevated serum squamous cell carcinoma (SCC) antigen (SCC‐Ag) levels and shorter survival in cancer patients. Few studies, however, have investigated the role of serum SCC‐Ag levels in oral SCC (OSCC).