Expression of large quantities of rheumatoid factor major cross-reactive idiotype in the serum of adults with seropositive rheumatoid arthritis

✍ Scribed by Josiah F. Wedgwood; Lynda Hatam; Vincent R. Bonagura

• Publisher: John Wiley and Sons
• Year: 1991
• Tongue: English
• Weight: 590 KB
• Volume: 34
• Category: Article
• ISSN: 0004-3591
• DOI: 10.1002/art.1780340709

✦ Synopsis

We quantified rheumatoid factor cross-reactive idiotype (RF-CRI) in whole serum from RF+ rheumatoid arthritis (RA) patients, using an inhibition enzymelinked immunosorbent assay which is not affected by the presence of IgG. Serum from 16 RF+ RA patients contained 2-252 pg/ml RF-CRI (geometric mean */i SD 20.8 */i 5.2), while serum from 11 normal adults contained 1-16 pg/ml RF-CRI (geometric mean */+ SD 3.9 */i 2.3). Serum from 8 of the RF+ RA patients contained RF-CRI at concentrations more than 2 standard deviations above the geometric mean in the normal subjects (>21 pglml). Our results indicate that some RF+ RA patients express high concentrations of RF-RCRI and immunoglobulin molecules that express the RF-CRI may not be RF.

In 1973, Kunkel and coworkers reported that human monoclonal 19s IgM rheumatoid factors (RF) obtained from patients with Waldenstrom's macroglo-From the Divisions of Allergy, Immunology and Rheuma-