Expression of Ku80 correlates with sensitivities to radiation in cancer cell lines of the head and neck
β Scribed by Hyo Won Chang; Sang Yoon Kim; So-Lyoung Yi; Se-Hee Son; Do Young Song; Su Young Moon; Jong Hoon Kim; Eun Kyung Choi; Seung Do Ahn; Seong Soo Shin; Kang Kyoo Lee; Sang-wook Lee
- Book ID
- 113832713
- Publisher
- Elsevier Science
- Year
- 2006
- Tongue
- English
- Weight
- 883 KB
- Volume
- 42
- Category
- Article
- ISSN
- 1368-8375
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## Abstract ## Background Cisplatin treatment is beneficial for approximately 20% of patients with head and neck squamous cell carcinoma (HNSCC). Tools to predict the clinical outcome and evaluate intrinsic cisplatin sensitivity are, therefore, required. ## Methods Cisplatin sensitivity, lysosom
The authors established five cell lines from a human head and neck tumor. The five cell lines (HC-2, HC-3, HC-4, HC-7, and HC-9) exhibited different sensitivities to Adriamycin, cisplatin, bleomycin, 5- fluorouracil, vincristine, and daunomycin. The Dw was 200 ng/ml Adriamycin (doxorubicin) for HC-7