## Abstract ## Background Proteins regulating the cell cycle and cell death are frequently abnormally expressed in cancer. Several of these, particularly p53 and Bclβ2, have been widely suggested as possible prognostic markers in diverse human malignancies. Their role in predicting outcome in squa
Expression of iNOS, p53, and VEGF in laryngeal squamous cell carcinoma
β Scribed by Hiroshi Shigyo; Satoshi Nonaka; Takeshi Ogino; Akihiro Katayama; Hideyuki Ishii; Masanobu Imada; Yasuaki Harabuchi
- Book ID
- 117399505
- Publisher
- SAGE Publications
- Year
- 2003
- Tongue
- English
- Weight
- 44 KB
- Volume
- 129
- Category
- Article
- ISSN
- 0194-5998
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We investigated immunohistochemically the clinical relevance of the over-expression of the apoptosis-regulating proteins p53 and bcl-2 in a homogeneous series of 149 laryngeal squamous-cell carcinomas. p53 was over-expressed in 75 cases and bcl-2 in 39 cases. p53 and bcl-2 co-expression was found in
One-hundred-two patients with laryngeal squamous cell carcinomas in Northeast China were examined for human papillomavirus (HPV) DNA by the polymerase chain reaction (PCR) coupled with Southern blot hybridization, and for p53 over-expression by immunohistochemical staining. HPV DNAs were found in 60