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Expression of immunoglobulin delta chain causes allelic exclusion in transgenic mice

✍ Scribed by Iglesias, Antonio; Lamers, Marinus; Köhler, Georges

Book ID
109751479
Publisher
Nature Publishing Group
Year
1987
Tongue
English
Weight
378 KB
Volume
330
Category
Article
ISSN
0028-0836

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Allelic exclusion in transgenic mice exp
Allelic exclusion in transgenic mice expressing a heavy chain disease-like human μ protein
✍ Daniel Corcos; Antonio Iglesias; Olga Dunda; Jacques Jami 📂 Article 📅 1991 🏛 John Wiley and Sons 🌐 English ⚖ 844 KB

## Abstract Heavy chain diseases (HCD) are neoplastic proliferations of B cells which secrete truncated immunoglobulin heavy chains without associated light chains. These proteins are encoded by mutated genes which may also give rise to truncated membrane immunoglobulins. The neoplastic cells proli