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Expression of a microinjected immunoglobulin gene in the spleen of transgenic mice

✍ Scribed by Brinster, Ralph L.; Ritchie, Kindred A.; Hammer, Robert E.; O'Brien, Rebecca L.; Arp, Benjamin; Storb, Ursula

Book ID
109732768
Publisher
Nature Publishing Group
Year
1983
Tongue
English
Weight
714 KB
Volume
306
Category
Article
ISSN
0028-0836

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Previously, mouse zygotes were microinjected with the recombinant plasmid pMA3, which contains the Herpes simplex virus thymidine kinase gene attached to the promoter region of the Rous sarcoma virus (Gazaryan et al. 1984a). In the present work the pMA3 fragment with the flanking genomic sequences w