## Abstract ## Objective To determine the role and expression of the cytokine/receptor pair interleukinโ21 (ILโ21)/ILโ21 receptor (ILโ21R) in rheumatoid arthritis (RA). ## Methods The expression of ILโ21R and ILโ21 was analyzed by TaqMan realโtime polymerase chain reaction (PCR) and in situ hybr
โฆ LIBER โฆ
Expression of IL-21 receptor in synovial tissue and blood of patients with rheumatoid arthritis
โ Scribed by Frleta, M.; King, V.; Reilly, J. H.; Kerr, S.; Gilchrist, D. S.; Tornehave, D.; Lundsgaard, D.; Miller, A. M.; McInnes, I. B.
- Book ID
- 126968413
- Publisher
- BMJ Publishing Group
- Year
- 2012
- Tongue
- English
- Weight
- 76 KB
- Volume
- 71
- Category
- Article
- ISSN
- 0003-4967
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## Abstract ## Objective CD16 (IgG Fcฮณ receptor type IIIA [FcฮณRIIIA])โexpressing CD14+ monocytes express high levels of Tollโlike receptor 2 (TLRโ2) and are able to efficiently produce proinflammatory cytokines such as tumor necrosis factor ฮฑ (TNFฮฑ). To understand the role of CD16 and TLRโ2 in mon