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Expression of human poly(ADP-ribose) polymerase with DNA-dependent enzymatic activity inEscherichia coli

✍ Scribed by Miyoko Ikejima; Shigeru Noguchi; Rumiko Yamashita; Hisanori Suzuki; Takashi Sugimura; Masanao Miwa

Book ID: 115762294
Publisher: Elsevier Science
Year: 1989
Tongue: English
Weight: 945 KB
Volume: 163
Category: Article
ISSN: 0006-291X
DOI: 10.1016/0006-291x(89)92285-7

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## Abstract Poly(ADP‐ribosyl)ation is a post‐translational modification of protein occurring in the nucleus by poly(ADP‐ribose) polymerase enzyme activity. The main role of poly(ADP‐ribose) polymerase system as “nick sensor” and DNA breaks repair is based on its activation via DNA strand breaks. Fu