Expression of human erythropoietin directed by mWAP promoter in mammary gland of transgenic mice
β Scribed by Xuchen Zhang; Guoxiang Cheng; Jianquan Chen; Yong Cheng; Yingrun Wei; Wulan Yao; Shaofu Xu; Weide Lao
- Publisher
- Springer
- Year
- 2000
- Tongue
- English
- Weight
- 268 KB
- Volume
- 45
- Category
- Article
- ISSN
- 1001-6538
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## Abstract Whey acidic protein (WAP) is a major whey protein secreted in rodents' milk. Murine WAP (mWAP) genes have been assumed to be expressed solely in the mammary gland. However, several heterologous genes fused with the mWAP promoter and artificially introduced into animal genomes as transge
To develop transgenic mice, a mouse metallothionein promoter-human growth hormone (Mt-hGH) gene fragment was injected into the pronucleus of C57BI X DBN2J F, onecell embryos. Six founder animals grew larger (I 3-2.2 times) than littermate controls and had higher levels of hGH in plasma (4.6279 mUII)