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Expression of full-length human pro-urokinase in mammary glands of transgenic mice

✍ Scribed by Yaroslav Gursky; Robert Bibilashvili; Mikchail Minashkin; Alex Krasnov; Alex Deikin; Tatyana Ermolkevich; Andrey Popov; Lilia Verbovaya; Nicolai Rutkevich; Alexsander Shevelev; Sofia Georgieva; Sergey V. Razin; Igor Goldman; Elena Sadchikova

Publisher
Springer Netherlands
Year
2009
Tongue
English
Weight
260 KB
Volume
18
Category
Article
ISSN
0962-8819

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A prominent phenotype of plasmin deficiency in mice is reduced metastasis in the MMTV-PymT transgenic breast cancer model. Proteolytically active plasmin is generated from inactive plasminogen by one of 2 activators, uPA or tPA. We now find that uPA deficiency alone significantly reduces metastasis