Expression of Human Cyclophilin-40 and the Effect of the His141→Trp Mutation on Catalysis and Cyclosporin A Binding
✍ Scribed by Kai Hoffmann; Lazaros T. Kakalis; Karen S. Anderson; Ian M. Armitage; Robert E. Handschumacher
- Book ID
- 115131153
- Publisher
- John Wiley and Sons
- Year
- 1995
- Tongue
- English
- Weight
- 673 KB
- Volume
- 229
- Category
- Article
- ISSN
- 1432-1327
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📜 SIMILAR VOLUMES
Human cyclophilin A (hCypA) contains one tryptophan residue at position 121 (Trp121). The fluorescence intensity of this single tryptophan residue doubles upon binding the clinically important immunosuppressant cyclosporin A (CsA). Trp121 is in close contact to the bound CsA and is well-conserved in
The aim of this study was to elucidate the possible causes of elevated low-density lipoprotein (LDL)-cholesterol levels in patients with transplants who were treated with the immunosuppressant drug cyclosporine A (CSA). The binding and internalization of (125)I-LDL in the presence or absence of CSA
**It no longer takes two**. We report on cyclosporin A (CsA) derivatives that inhibit calcineurin protein phosphatase activity without first forming a binary complex with cyclophilin 18. Furthermore, these derivatives are rapid binding inhibitors for cyclophilin 18, whereas CsA is a slow binding inh