𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Expression of Human Cyclophilin-40 and the Effect of the His141→Trp Mutation on Catalysis and Cyclosporin A Binding

✍ Scribed by Kai Hoffmann; Lazaros T. Kakalis; Karen S. Anderson; Ian M. Armitage; Robert E. Handschumacher


Book ID
115131153
Publisher
John Wiley and Sons
Year
1995
Tongue
English
Weight
673 KB
Volume
229
Category
Article
ISSN
1432-1327

No coin nor oath required. For personal study only.


📜 SIMILAR VOLUMES


Tryptophan microstate reshuffling upon t
✍ Mireille Gastmans; Guido Volckaert; Yves Engelborghs 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 188 KB

Human cyclophilin A (hCypA) contains one tryptophan residue at position 121 (Trp121). The fluorescence intensity of this single tryptophan residue doubles upon binding the clinically important immunosuppressant cyclosporin A (CsA). Trp121 is in close contact to the bound CsA and is well-conserved in

Effect of cyclosporine A on the binding
✍ Kishor M. Wasan; Elizabeth M. Donnachie; David W. Seccombe; P. Haydn Pritchard 📂 Article 📅 2002 🏛 John Wiley and Sons 🌐 English ⚖ 70 KB

The aim of this study was to elucidate the possible causes of elevated low-density lipoprotein (LDL)-cholesterol levels in patients with transplants who were treated with the immunosuppressant drug cyclosporine A (CSA). The binding and internalization of (125)I-LDL in the presence or absence of CSA

Branches on the α-C Atom of Cyclosporin
✍ Yixin Zhang; Ria Raumgrass; Mike Schutkowski; Gunter Fischer 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 English ⚖ 119 KB

**It no longer takes two**. We report on cyclosporin A (CsA) derivatives that inhibit calcineurin protein phosphatase activity without first forming a binary complex with cyclophilin 18. Furthermore, these derivatives are rapid binding inhibitors for cyclophilin 18, whereas CsA is a slow binding inh