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Branches on the α-C Atom of Cyclosporin A Residue 3 Result in Direct Calcineurin Inhibition and Rapid Cyclophilin 18 Binding

✍ Scribed by Yixin Zhang; Ria Baumgrass; Mike Schutkowski; Gunter Fischer

Publisher
John Wiley and Sons
Year
2004
Tongue
English
Weight
48 KB
Volume
5
Category
Article
ISSN
1439-4227

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Branches on the α-C Atom of Cyclosporin
Branches on the α-C Atom of Cyclosporin A Residue 3 Result in Direct Calcineurin Inhibition and Rapid Cyclophilin 18 Binding
✍ Yixin Zhang; Ria Raumgrass; Mike Schutkowski; Gunter Fischer 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 English ⚖ 119 KB

**It no longer takes two**. We report on cyclosporin A (CsA) derivatives that inhibit calcineurin protein phosphatase activity without first forming a binary complex with cyclophilin 18. Furthermore, these derivatives are rapid binding inhibitors for cyclophilin 18, whereas CsA is a slow binding inh