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Expression of hepatitis C virus NS5A natural mutants in a hepatocytic cell line inhibits the antiviral effect of interferon in a PKR-independent manner

✍ Scribed by Philippe Podevin; Abdelmajid Sabile; Rodrigo Gajardo; Nadira Delhem; Annie Abadie; Pierre-Yves Lozach; Laura Beretta; Christian Bréchot


Book ID
111721522
Publisher
John Wiley and Sons
Year
2001
Tongue
English
Weight
550 KB
Volume
33
Category
Article
ISSN
0270-9139

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The hepatitis C virus (HCV) nonstructural 5A (NS5A) protein has been implicated in the inherent resistance of HCV to interferon (IFN) antiviral therapy in clinical studies. Biochemical studies have demonstrated that NS5A interacts in vitro with and inhibits the IFN-induced, RNAdependent protein kina