Expression of glial cell line–derived neurotrophic factor family members and their receptors in pancreatic cancers
✍ Scribed by Yoshinori Ito; Yuji Okada; Mikinori Sato; Hirozumi Sawai; Hitoshi Funahashi; Takayuki Murase; Tetsushi Hayakawa; Tadao Manabe
- Book ID
- 113920173
- Publisher
- Elsevier Science
- Year
- 2005
- Tongue
- English
- Weight
- 697 KB
- Volume
- 138
- Category
- Article
- ISSN
- 0039-6060
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Glial cell line-derived neurotrophic factor (GDNF) has been shown to exert neurotrophic effects on motor neurons as well as mesencephalic dopaminergic neurons. Because GDNF promotes survival of motor neurons in vivo and in vitro and rescues motor neurons from naturally occurring cell death, the pote
## Abstract ## Aims: Glial cell‐line derived neurotrophic factor (GDNF) and related factors neurturin (NRTN), artemin, and persephin are members of the GDNF family of neurotrophic factors. GDNF and NRTN bind to the tyrosine kinase receptor Ret and the receptors GFRα1 and GFRα2. The objective was t