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Expression of galactose-1-P-uridyltransferase in Chinese hamster × human galactosemia somatic cell hybrids

✍ Scribed by Robert S. Sparkes; T. Mohandas; Maryellen C. Sparkes; Jeffery D. Shulkin

Publisher
Springer
Year
1979
Tongue
English
Weight
492 KB
Volume
17
Category
Article
ISSN
0006-2928

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✦ Synopsis

Lymphocy tes from a patient with classic galactosemia (GA LT deficiency) were hybridized with a Chinese hamster cell line. Electrophoretic evaluation of GAL T in 31 independently derived interspecific hybrid clones failed to demonstrate expression of the human GALT gene even when human chromosome 9 was present. Possible mechanisms for this lack of expression are presented.

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