✦ LIBER ✦
Expression of the human adenylate kinase isozymes, phosphopyruvate hydratase, 6-phosphogluconate dehydrogenase, and phosphoglucomutase-1 in man-rodent somatic cell hybrids
✍ Scribed by Gail A. P. Bruns; Park S. Gerald
- Publisher
- Springer
- Year
- 1976
- Tongue
- English
- Weight
- 984 KB
- Volume
- 14
- Category
- Article
- ISSN
- 0006-2928
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✦ Synopsis
The expression of the adenylate kinase isozymes and of phosphopyruvate hydratase was studied in man-mouse and man-hamster hybrid clones. Concordant segregation of the loci coding for AK-2 and PPH was observed in 54 of 55 primary hybrid clones, and these loci were demonstrated to be synthetic with the loci specifying PGM-1 and PGD. The pattern of expression of the four enzymes in discordant clone suggests the gene order 1pter-(PGD, PPH)-AK-2-PGM-1-centromere. In addition, AK-1 was found to be expressed independently of AK-2.