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Expression of feline type-C virus in normal and tumor tissues of the domestic cat

✍ Scribed by Reuven Levin; Sandra K. Ruscetti; Wade P. Parks; Edward M. Scolnick

Publisher
John Wiley and Sons
Year
1976
Tongue
French
Weight
967 KB
Volume
18
Category
Article
ISSN
0020-7136

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✦ Synopsis

Abstract

Tumor and normal tissues from domestic cats were examined for FeLV and RD‐114 specific nucleic acids and proteins. Virus‐positive tissues showed a 100‐ to 200‐fold higher level of FeLV and a 200‐ to 400‐fold higher level of FeLV p30 than virus‐negative tumors and normal cat tissues. In contrast, the levels of RD‐114 viral RNA and p30 antigen were comparable in the majority of tumorous and normal tissues examined. When the DNA of these tissues was examined for FeLV‐related sequences, the virus‐positive tumors were found to contain extra copies of FeLV DNA. Virus‐negative tumors contained DNA sequences homologous with FeLV but the copy number of these sequences could not be distinguished from normal tissues. The results indicate that in certain FeLV‐induced type‐C lymphoproliferative diseases, extra type‐C sequences not present in normal tissues can be identified.

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