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Expression of extracellular matrix proteases by fetal and adult murine skin fibroblasts cultured in in vitro matrices

✍ Scribed by E.R Island; H Wu; D Warburton; K Anderson; T.L Tuan


Book ID
114123653
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
139 KB
Volume
57
Category
Article
ISSN
0149-7944

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In vitro human skin fibroblasts aging was characterized by a continuous increase of collagenase mRNA levels. On the contrary, TIMP‐1 mRNA level decreased only at late passages (> 65% of proliferative life span). Type I and III mRNA levels showed a high variability depending on cell strains studied.